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NR449 Evidence based Practice

HEAL100 Health Care — exam and revision material · Other

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Health Care exam material, 9 pages. Originally published on StudyMerit.

Pages
9
Academic year
2025/2026
Language
English

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1 NR449 Evidence-Based Practice- RUA: Analyzing Published Research (Your Name Here) Name of the University or College NR449 Evidence-Based Practice Name of the Professor Date

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2 RUA: Analyzing Published Research Problem/Clinical Question The problem that our group is focusing on is how oxygen therapy can help avert hypoxia and subsequent organ failure in patients with Chronic Obstructive Pulmonary Disease. COPD, a progressive lung disease, characterized by airflow limitation and persistence respiratory symptoms, which usually lead to hypoxemia (low blood oxygen level) as well as system complication like organ dysfunction. COPD remains one of the major causes of morbidity and mortality in most parts of the world, affecting millions of patients. Hypoxia can lead to exacerbation of respiratory failure with complications like right heart failure, cognitive decline, and an overall decrease in quality of life. The available statistics estimate that over 16 million people in the United States have a diagnosis of COPD, and it is a leading cause of hospitalization. Oxygen therapy has proved to reduce hospital admissions by alleviating hypoxia and thus reducing mortality, which ultimately leads to the improved patients’ outcome. The PICOT question formulated for our group is: " In patients with COPD (P), how does oxygen therapy (I) compared to no oxygen therapy or lower oxygen use (C) affect the reduction of hypoxia and prevention of organ failure (O) over a period of time (T)?" The purpose of this paper is to interpret the two articles identified as most important to the group topic of whether oxygen therapy is effective in reducing hypoxia and preventing organ failure among patients with COPD (examining how oxygen therapy help with hypoxia and organ failure in patients with COPD.).

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3 Synthesis of Literature The Evidence Matrix Table assists in summarizing the major findings of two significant studies related to oxygen therapy in COPD patients. The first is a randomized controlled trial study conducted by Lacasse et al., (2020), and the second study is a systematic review and meta-analysis by Sami et al., (2023), both of which examine the effects of oxygen therapy in patients with COPD. They vary in scope, design, and results; therefore, they provide diverse pieces of information about the clinical problem. Variables: Variables in each study vary depending on the type of investigation. In the Lacasse et al. (2020) study, for example, the independent variable relates to the nocturnal oxygen therapy administration, while the dependent variables include survival rates and disease progression to long-term oxygen therapy. On the contrary, Sami et al. (2023) explain how LTOT leads to differences in rehospitalization rates; LTOT is the independent variable while rehospitalization rates is the dependent variable. Though the two studies discuss oxygen therapy, the variables of each further depict their different fields of focus: mortality and hospitalization in the former, while in the latter, it is the rehospitalization rate. Methods: Lacasse et al. (2020) utilized a quantitative RCT design, where patients with moderate COPD were randomly assigned to receive either nocturnal oxygen therapy or a placebo treatment, in order to compare their respective outcomes across time. As an RCT, this study is considered higher-level evidence (high level confidence) since an RCT generally offers great confidence in the findings due to controlled conditions. On the contrary, Sami et al. (2023) make use of the systematic review with a meta-analysis, which is a higher level of evidence where data from several studies are combined. The meta-analysis also makes use of a quantitative approach where data from seven studies are combined to assess the effects of LTOT. The two

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