Test Bank for Human Genetics, 11th Edition

Chapter 02 – Cells Chapter 02 Cells Multiple Choice Questions 1. The cellular basis of muscular dystrophy is that some of a child’s muscle cells A. have combined into a structure that cannot contract. B. lack DNA. C. lack a protein that enables them to withstand the force of contraction. D. have too much of a contractile protein and become weak. Bloom’s Level: 02. Understand Learning Outcome: 02.01 Explain why it is important to know the cellular basis of a disease. Section: 02.01 Topic: Cell parts 2. A researcher identifies an abnormality in a protein that causes a particular inherited illness. To develop a treatment, it would be most helpful to know A. which cells are affected and how to replace the protein’s function in them. B. the sequence of the gene that encodes the protein. C. the other types of molecules that cause or contribute to the disease. D. the type of mutation that affects the protein. Bloom’s Level: 03. Apply Learning Outcome: 02.01 Explain why it is important to know the cellular basis of a disease. Section: 02.01 Topic: Cell parts 2-1 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 3. Which of the following statements is true? A. Somatic cells are diploid, meaning that they have two copies of the human genome. B. Somatic cells are haploid, meaning that they have one copy of the human genome. C. Sperm and egg cells are diploid, meaning that they have two copies of the human genome. D. Stem cells are haploid, meaning that they have one copy of the human genome. Bloom’s Level: 02. Understand Learning Outcome: 02.02 Define differentiated cell. Section: 02.01 Topic: Cell parts 4. Which of the following types of components aggregate and interact to form the epithelial, connective, muscle, and nerve tissues in the human body? A. Prokaryotic cell B. Secondary meristems C. Differentiated cell D. Stem cell Bloom’s Level: 01. Remember Learning Outcome: 02.02 Define differentiated cell. Section: 02.01 Topic: Differentiation 2-2 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 5. Humans belong to domain _____, which is distinguished by cells that have _____. A. Prokarya; organelles B. Archaea; ancient organelles C. Eukarya; organelles D. Prokarya; proteins Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 6. Ribosomes are in the cells of A. eukaryotes only. B. animals only. C. vertebrates only. D. all organisms. Bloom’s Level: 01. Remember Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 7. The major macromolecules that make up cells are A. vitamins and minerals. B. carbon, hydrogen, nitrogen, oxygen, and phosphorus. C. carbohydrates, proteins, lipids, and nucleic acids. D. eukaryotes, prokaryotes, and archaea. Bloom’s Level: 01. Remember Learning Outcome: 02.03 List the four major chemicals in cells. Section: 02.02 Topic: Cell parts 2-3 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 8. About _____ average-sized bacteria could fit into a human cell. A. 10 B. 100 C. 1,000 D. 10,000 Bloom’s Level: 01. Remember Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 9. Organelles protect a cell by A. sequestering biochemicals that could dismantle other cellular structures. B. forming a thick outer barrier. C. containing powerful enzymes that kill any bacteria that enter. D. placing flag-like molecules on a cell’s surface, which identify that cell as belonging to a particular person. Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 10. The nuclear lamina is A. the sac that holds the genetic material. B. part of the nucleus that holds RNA. C. a fibrous layer that lines the inner face of the nuclear membrane. D. the site of protein synthesis. Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 2-4 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 11. In a human cell, the genetic material is in the A. lysosome. B. ribosome. C. nucleus. D. cytoplasm. Bloom’s Level: 01. Remember Learning Outcome: 02.03 List the four major chemicals in cells. Section: 02.02 Topic: Cell parts 12. Which of the following acts as a quality control center for cells? A. Lysosome B. Plasma membrane C. Endoplasmic reticulum D. Nuclear lamina Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 2-5 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 13. What is the sequence of events involved in the production of proteins that is secreted? A. A hormone signals the gene that encodes the protein to be transcribed into mRNA in the nucleus. The mRNA is translated into protein on the ER, then processed and folded in the Golgi apparatus, and then sent out of the cell in a vesicle. B. A hormone signals a protein-filled vesicle to move from the plasma membrane into the cell and into the nucleus, where it stimulates transcription of the appropriate gene into mRNA. The mRNA exits the nucleus and is translated into protein on the ER and processed and folded in the Golgi apparatus. Finally, the protein is transported out of the cell in a vesicle. C. A hormone binds to the plasma membrane, signaling proteins near the membrane to fall apart into amino acids. These enter the nucleus and stimulate replication of the gene encoding the protein. D. The protein is produced as a linear molecule in the nucleus, then exits through nuclear pores. On the ER the protein folds into its active form and at the Golgi apparatus is packed into a vesicle, which carries it across the plasma membrane and out of the cell. Bloom’s Level: 01. Remember Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 14. The organelle that consists of a stack of flat, membrane-enclosed sacs is the A. mitochondrion. B. nucleolus. C. Golgi apparatus. D. nucleus. Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 15. The organelle that is the equivalent of a cellular garbage disposal system is the A. nucleus. B. lysosome. C. mitochondrion. D. glucosome. Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 2-6 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 16. A type of vesicle that ferries molecules, such as cholesterol, to lysosomes is an A. endosome. B. episome. C. oprahsome. D. ectosome. Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 17. In mitochondria, A. energy from nutrients is converted into a form that a cell can use. B. all of a cell’s DNA is replicated. C. fats and carbohydrates are degraded. D. sugars are added to proteins. Bloom’s Level: 01. Remember Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 18. The cell type with the most mitochondria is A. muscle. B. nerve. C. fat. D. sperm. Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 2-7 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 19. Cristae are A. types of genes. B. types of insects. C. membranous structures that are parts of mitochondria. D. bits of sugars in the Golgi apparatus. Bloom’s Level: 01. Remember Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 20. In a DNA molecule, the sugar-phosphate backbone is the same in everyone, but the base sequence is different in everyone. A plasma membrane is similar conceptually to DNA in that A. the lipid bilayer is the same in everyone, but the nature and pattern of the molecules embedded in it differ. B. the pattern of embedded proteins in the plasma membrane is the same in everyone, but the lipid bilayer differs. C. the lipid bilayer and pattern of embedded proteins differ in everyone. D. the lipid bilayer is the same in everyone, but some people have the embedded proteins sticking out of the outer face of the membrane, and others have the proteins extending inward. Bloom’s Level: 04. Analyze Learning Outcome: 02.05 Describe the structure and function of a biological membrane. Section: 02.02 Topic: Cell parts 21. Which sequence of events illustrates the steps of signal transduction? A. First messenger to receptor molecules to second messenger to cellular response B. Receptor molecules to first messenger to second messenger to cellular response C. First messenger to second messenger to receptor molecules to cellular response D. First messenger to second messenger to cellular responses to receptor Bloom’s Level: 04. Analyze Learning Outcome: 02.05 Describe the structure and function of a biological membrane. Section: 02.02 Topic: Cell parts 2-8 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 22. A molecule that binds a cell surface receptor is called a A. peroxisome. B. nucleic acid. C. ligand. D. nuclear pore. Bloom’s Level: 01. Remember Learning Outcome: 02.05 Describe the structure and function of a biological membrane. Section: 02.02 Topic: Cell parts 23. The internal scaffolding of a cell consists of A. microtubules and microfilaments. B. cilia and flagella. C. chitin and chlorophyll. D. lipid bilayers. Bloom’s Level: 01. Remember Learning Outcome: 02.06 List the components of the cytoskeleton. Section: 02.02 Topic: Cell parts 24. Cilia are built of A. microorganisms. B. microfilaments. C. micronutrients. D. microtubules. Bloom’s Level: 01. Remember Learning Outcome: 02.06 List the components of the cytoskeleton. Section: 02.02 Topic: Cell parts 2-9 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 25. The cytoskeletal component that consists of different protein types is: A. a microtubule. B. an intermediate filament. C. a microfilament. D. a fibrous filament. Bloom’s Level: 02. Understand Learning Outcome: 02.04 Describe how organelles interact. Section: 02.02 Topic: Cell parts 26. People with giant axons lose the ability to move and see because A. apoptosis in their body rapidly and neatly dismantles cells into membrane-enclosed pieces that a phagocyte can mop up. B. they lack a protein, called gigaxonin, which normally breaks down intermediate filaments and recycles their components. C. they have an excess of CFTR proteins, which entrap salt inside cells. D. their hemoglobin leaks out of the cells of the body. Bloom’s Level: 02. Understand Learning Outcome: 02.06 List the components of the cytoskeleton. Section: 02.02 Topic: Cell parts 2-10 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 27. The approximate percentage of our cells that are replaced daily is A. 0.1%. B. 1%. C. 10%. D. 27% Bloom’s Level: 01. Remember Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 28. The two major stages of the cell cycle are A. interphase and prophase. B. interphase and mitosis. C. mitosis and meiosis. D. mitosis and apoptosis. Bloom’s Level: 01. Remember Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 29. The cell cycle is a series of events a cell undergoes as it prepares to A. divide. B. die. C. adhere to another cell. D. pass along a signal. Bloom’s Level: 01. Remember Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 2-11 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 30. DNA replicates during the _____ phase of the cell cycle. A. G1 B. G2 C. G3 D. S Bloom’s Level: 02. Understand Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 31. The order of events in the cell cycle is A. S to G1 to G2 to mitosis. B. Mitosis to G1 to G2 to S. C. G1 to G2 to S to mitosis. D. G1 to S to G2 to mitosis. Bloom’s Level: 04. Analyze Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 32. At the point in the cell cycle when mitosis begins A. DNA replication begins. B. each chromosome consists of two identical chromatids joined at the centromere. C. the number of chromosome is reduced to half. D. the cell enters a dormant phase. Bloom’s Level: 02. Understand Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 2-12 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 33. Chromosomes coil tightly around chromosomal proteins and condense during A. prophase. B. metaphase. C. anaphase. D. telophase. Bloom’s Level: 01. Remember Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 34. Cells contain twice the normal number of chromosomes briefly during A. prophase. B. metaphase. C. anaphase. D. telophase. Bloom’s Level: 01. Remember Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 35. During S phase, replicated chromosomes are joined at their A. centrosomes. B. centromeres. C. middlemeres. D. telomeres. Bloom’s Level: 02. Understand Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell parts 2-13 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 36. The part of a chromosome that shortens with each cell division, functioning as a “clock,” is the A. centromere. B. centrosome. C. centriole. D. telomere. Bloom’s Level: 01. Remember Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 37. Factors that control how often a cell divides include A. telomere lengths, hormonal signals, crowding, and growth factors. B. which chromosomes are active and which are not. C. the activity level of the person, diet, and environmental exposures. D. where chromosomes are located within the nucleus. Bloom’s Level: 02. Understand Learning Outcome: 02.08 Describe the events and control of the cell cycle. Section: 02.03 Topic: Cell division and death 38. During apoptosis, caspases A. activate enzymes that cut DNA into same-sized pieces. B. cause mitochondria to replicate their DNA. C. alter the cell surface so that viruses can more easily enter. D. remove introns from DNA. Bloom’s Level: 02. Understand Learning Outcome: 02.07 Distinguish between mitosis and apoptosis. Section: 02.03 Topic: Cell division and death 2-14 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 39. Apoptosis is a form of A. programmed cell death that is a normal part of development. B. programmed cell division that is a normal part of development. C. cellular duplication. D. cellular adhesion. Bloom’s Level: 01. Remember Learning Outcome: 02.07 Distinguish between mitosis and apoptosis. Section: 02.03 Topic: Cell division and death 40. The defining characteristic of a stem cell is A. self-repair. B. self-renewal. C. the ability to turn into a cancer cell. D. its origin from a progenitor cell. Bloom’s Level: 01. Remember Learning Outcome: 02.09 List the characteristics of a stem cell. Section: 02.04 Topic: Stem cells 41. A difference between a stem cell and a progenitor cell is that A. a progenitor cell cannot self-renew and a stem cell can. B. a stem cell cannot self-renew and a progenitor cell can. C. progenitor cells are rare but stem cells are abundant. D. progenitor cells are not present in embryos but stem cells are. Bloom’s Level: 02. Understand Learning Outcome: 02.10 Define stem and progenitor cell. Section: 02.04 Topic: Stem cells 2-15 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 42. A cell that can divide to give rise to any cell type, including those of membranes that support the developing embryo, is A. multipotent. B. a progenitor cell. C. a differentiated cell. D. totipotent. Bloom’s Level: 02. Understand Learning Outcome: 02.09 List the characteristics of a stem cell. Section: 02.04 Topic: Stem cells 43. An experimental treatment for amyotrophic lateral sclerosis (Lou Gehrig’s disease), which causes gradual loss of the ability to move, sends four genes into cells sampled from a patient’s skin. This procedure reprograms the cells, which are then exposed to molecules and genes that stimulate them to develop as healthy versions of the cells affected in the disease. These cells are implanted into the patient. They are A. embryonic stem cells. B. adult connective tissue stem cells. C. induced pluripotent stem cells. D. apoptotic cells. Bloom’s Level: 04. Analyze Learning Outcome: 02.10 Define stem and progenitor cell. Section: 02.04 Topic: Stem cells 44. Human embryonic stem cells that are used in research are A. cultured in the bodies of human embryos from outer cell mass cells. B. cultured in laboratory dishes from inner cell mass cells taken from a 5-day embryo. C. taken from aborted human fetuses between 10 and 12 weeks of gestation. D. taken from stillbirths that do not have genetic diseases. Bloom’s Level: 02. Understand Learning Outcome: 02.09 List the characteristics of a stem cell. Section: 02.04 Topic: Stem cells 2-16 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 45. “Adult” stem cells are more accurately called tissue-specific or somatic stem cells because A. they are also present at prenatal stages of development. B. some adults do not have them. C. whether they are present or not in an adult depends upon the individual’s level of maturity. D. an adult body also contains embryonic stem cells. Bloom’s Level: 02. Understand Learning Outcome: 02.09 List the characteristics of a stem cell. Section: 02.04 Topic: Stem cells 46. Human stem cells are valuable in drug development because they can be used to A. create experimental organisms, such as rats and mice. B. replace experimental animals such as rats and mice. C. grow human embryos in culture, on which drugs can be tested. D. study the latest stages of the disease that would have unfolded if the person hadn’t died. Bloom’s Level: 02. Understand Learning Outcome: 02.09 List the characteristics of a stem cell. Section: 02.04 Topic: Stem cells 2-17 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 47. The cells within and on us that are not actually of us constitute the A. human microbiome. B. parasite family. C. prokaryotic cells. D. cytoskeleton. Bloom’s Level: 01. Remember Learning Outcome: 02.11 How can the bacteria that live in and on our bodies affect our health? Section: 02.05 Topic: The human microbiome 2-18 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 48. Which of the following is a cure for people with recurrent infection from Clostridium difficile? A. Renal transplantation B. Genetic restructuring C. Grafting D. Fecal transplantation Bloom’s Level: 02. Understand Learning Outcome: 02.11 How can the bacteria that live in and on our bodies affect our health? Section: 02.05 Topic: The human microbiome 2-19 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 49. Which of the following is true of the human microbiome? A. High blood sugar following weight-loss surgery is partly due to a changed gut microbiome. B. An altered microbiome hastens starvation in malnourished children. C. Antibiotics do not alter the gut microbiome. D. The microbiome consists primarily of cells that belong to the human body. Bloom’s Level: 02. Understand Learning Outcome: 02.11 How can the bacteria that live in and on our bodies affect our health? Section: 02.05 Topic: The human microbiome 2-20 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education. Chapter 02 – Cells 50. Which of the following bacteria benefits humans? A. EnteritisSalmonella B. Probiotics C. Streptococcus Pyogenes D. Salmonella Typhi Bloom’s Level: 02. Understand Learning Outcome: 02.11 How can the bacteria that live in and on our bodies affect our health? Section: 02.05 Topic: The human microbiome 2-21 Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of McGraw-Hill Education.