Preview Extract
Chapter 2: Tissue Response to Injury
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____
1. What is the most common symptom for which an individual seeks medical attention?
A. Trauma to soft tissues
B. Obesity
C. Pain
D. Depression
____
2. Pain has sensory and psychological components that can complicate its accurate quantification.
Which of the following percentage relationships most accurately demonstrates the composition of
sensory and psychological components of pain?
A. 50% sensory and 50% psychological
B. 80% sensory and 20% psychological
C. 20% sensory and 80% psychological
D. There is no accurate relationship between the sensory and psychological
components.
____
3. Which of the following criteria is inconsistent with chronic pain?
A. The cause is well defined.
B. Medical treatments have been ineffective.
C. The painful symptoms have persisted for more than 3 months.
D. The cause is not correctable or is uncertain.
____
4. Which of the following terms best describes the phenomenon experienced by the patient when
painful symptoms are perceived in areas remote from the site of the original tissue damage?
A. Acute pain
B. Chronic pain
C. Referred pain
D. Phantom pain
____
5. Prior to an individual being aware of pain, the painful input to the dorsal horn of the spinal cord
must travel to the brain. Which of the following scenarios is most accurate in describing the path
to the brain?
A. The axons of most of the transmission cells cross over and ascend via the
spinothalamic tract.
B. The axons of most of the transmission cells ascend ipsilaterally via the
spinothalamic tract.
C. The axons of most of the transmission cells cross over and descend via the lateral
spinothalamic tract.
D. The axons of all of the transmission cells descend over the spinothalamic tract to
the brain.
____
6. Which of the following stimuli could result in the liberation of endogenous opiates?
A. Short duration, low intensity exercise
B. Sleeping
C. Intense pain
D. Eating an apple
____
7. Vascularized tissue responds to injury with a series of events that are referred to as inflammation
and repair. Which of the following statements is least accurate in describing the purpose of
inflammation?
A. Inflammation results in immobilization of the area.
B. Inflammation results in preparation of the area for repair.
C. Inflammation results in dysfunction and must be avoided.
D. Inflammation results in vasodilation to improve circulation.
____
8. The proliferative phase of healing involves the revascularization and rebuilding of tissues. Which
of the following is most accurate in describing tissues during this stage of healing?
A. Fragile
B. Hot
C. Bulky
D. Smooth
____
9. Which of the following statements is most accurate?
A. Scar tissue is as strong as the tissue it replaces.
B. Scar tissue is stronger than the tissue it replaces.
C. Scar tissue is not as strong as the tissue it replaces.
D. Scar tissue is 70% as strong as the tissue it replaces.
____
10. When surgical intervention is involved in the closure of a wound, it is termed โhealing by first
intention.โ Which of the following reasons would NOT be associated with promoting healing by
first intention?
A. Dirt in the wound
B. Infection
C. Excessive drainage
D. Physical condition of the patient
____
11. Which of the following endogenous substances is NOT released into an injured area as a normal
response to injury?
A. Potassium
B. Serotonin
C. Histamine
D. Glucose
____
12. Which of the following types of non-narcotic medications is often prescribed for analgesia but
tends to cause gastrointestinal irritation?
A. NSAIDs
B. Codeine
C. Morphine
D. Serotonin
____
13. A referral area of pain that follows the dermatome of a nerve is following what pattern?
A. The muscle that is supplied by that nerve
B. The bone that is supplied by that nerve
C. The skin that is supplied by that nerve
D. The organ that is supplied by that nerve
____
14. Pain receptors are responsible for signaling potential tissue damage. What is the name for this type
of receptor?
A. Motor fibers
B. Mechanoreceptors
C. Nociceptors
D. Thermoreceptors
____
15. Which of the following types of nociceptors has the fastest conduction velocity?
A. A-delta fibers
B. C-fibers
C. Small, unmyelinated C-fibers
D. Mechanoreceptors
____
16. Which of the following explanations is most accurate in helping to explain why chronic pain is
often difficult to localize?
A. Chronic pain persists long after the time of insult to the injured tissues.
B. Chronic pain is not difficult to localize; the statement is false.
C. A-beta fibers carry painful stimuli and they may travel several spinal segments
prior to entering the spinal gray matter.
D. Nociceptors commonly transmit stimuli from the nerve root through several
different segments.
____
17. Wide-dynamic-range cells are NOT responsible for the localization of which of the following
symptoms?
A. Burning or prickling
B. Touch
C. Motion
D. Noxious stimuli
____
18. The most basic premise behind Melzack and Wallโs gate control theory of pain is that:
A. Pain is a unique experience for all individuals, which can be qualified only by the
individual experiencing it.
B. Psychological factors influence pain perception, making it impossible to accurately
quantify.
C. Sensory stimuli can inhibit painful stimuli from reaching the brain.
D. There is an interaction of peripheral and central mechanisms that may or may not
elicit a painful response to noxious stimuli.
____
19. Which of the following statements is most accurate regarding clinical versus experimental pain?
A. Although the sensation is the same, results accomplished experimentally should
not be extrapolated to be identical in clinical pain syndromes.
B. The sensations are the same regardless of the method of production, which makes
extrapolation of data from experimental studies directly applicable to clinical pain
syndromes.
C. Experimental pain is easier to produce than clinical pain and is therefore of no use
for research purposes.
D. Clinical pain is unique to each individual, which makes experimental pain of no
use for research purposes.
____
20. Edema is a normal response during the inflammatory phase of the process of tissue healing. The
constituents of the edema change dependent upon the length of time that the edema is present and
the magnitude of the injury. Which statement is correct and why?
A. Transudates appear last and easily dissipate due to the vast number of leukocytes
present within.
B. Plasma proteins are first to help the lymphatic system to flush the area and
decontaminate it from necrotic tissues.
C. Exudates indicate that there is a break in the surface of the skin and represent the
presence of infection.
D. Pus contains large numbers of white blood cells and is often difficult to reduce.
Chapter 2: Tissue Response to Injury
Answer Section
MULTIPLE CHOICE
1. ANS: C
Feedback
A
B
C
D
Incorrect. Trauma alone may not cause enough significant tissue damage to
cause pain. For example, a bruise is the result of soft tissue trauma but rarely
causes someone to seek attention for it.
Incorrect. Although obesity is a major health concern in recent times, there has
been a rapid growth in the marketing of diets and diet products, which an
individual often seeks prior to medical advice.
Correct. Pain is the most common symptom that causes individuals to seek
medical attention.
Incorrect. Depression often is unreported and untreated by medical
professionals.
PTS: 1
2. ANS: D
KEY: pain | symptoms
Feedback
A
B
C
D
Incorrect. There are too many variables that contribute to a patientโs painful
experience to be able to establish a set percentage.
Incorrect. There are too many variables that contribute to a patientโs painful
experience to be able to establish a set percentage.
Incorrect. There are too many variables that contribute to a patientโs painful
experience to be able to establish a set percentage.
Correct. There are too many variables that contribute to a patientโs painful
experience to be able to establish a set percentage.
PTS: 1
3. ANS: A
KEY: psychology of pain | pain perception | painful sensation
Feedback
A
B
C
Correct. Chronic pain often is not well defined or easily localized.
Incorrect. Often, patients who have been diagnosed with conditions that have a
chronic pain component have been treated unsuccessfully by several means.
Incorrect. Painful symptoms that persist for more than 3 months are
characteristic of chronic pain. Acute pain often subsides in a much shorter period
of time.
D
Incorrect. Chronic pain syndromes can result from a variety of diagnoses that
may be so remote from the present symptoms that they are now unrelated or
difficult to trace back to the original insult. Some of these diagnoses are not
correctable and must be managed through therapeutic treatment interventions.
PTS: 1
4. ANS: C
KEY: chronic pain | pain definitions
Feedback
A
B
C
D
Incorrect. Acute pain is often experienced local to the site of insult to the soft
tissues.
Incorrect. Chronic pain may be referred or localized. However, the term chronic
does not refer to this quality of pain. Chronic refers to the time component since
the time of insult.
Correct. Referred pain is pain that arises from deep body structures but is felt at
another distant site.
Incorrect. Phantom pain is the term used to describe the sensation of pain being
perceived in an area that is no longer present. For example, an amputee may
experience the sensation of pain in the extremity that was amputated and is no
longer there. Hence, the term phantom is used to describe this phenomenon.
PTS: 1
5. ANS: A
KEY: chronic pain | acute pain | referred pain
Feedback
A
B
C
D
Correct. The crossing over of the cells prior to ascending is one of the reasons
that sensory stimulation at the spinal cord nerve root on either side can result in
pain reduction.
Incorrect. Ipsilaterally means โsame,โ and, in this scenario, pain experienced on
the right would ascend only on the right, which is inaccurate.
Incorrect. The tracts must ascend from the periphery to the brain, not descend.
Incorrect. The tracts must ascend from the periphery to the brain, not descend.
PTS: 1
6. ANS: C
KEY: pain pathways | spinal cord tracts | ascending tracts
Feedback
A
B
C
Incorrect. Intense exercise that persists for 10 to 20 minutes has been reported to
elicit the release of endorphins. Short duration, low intensity exercise has not.
Incorrect. Sleeping has not been shown to result in liberation of endogenous
opiates.
Correct. Intense pain has the ability to cause the liberation of endogenous
opiates. This may also be linked to the โfight or flightโ response that occurs in
D
emergency situations.
Incorrect. Eating an apple has not been shown to result in liberation of
endogenous opiates.
PTS: 1
7. ANS: C
KEY: acupuncture | endogenous opiates
Feedback
A
B
C
D
Incorrect. Inflammation may result in immobilization of the area. However, this
is necessary to prevent further injury to the involved tissues. The amount of
immobilization must be minimized to maintain motion in those areas that would
suffer a loss of motion if the immobilization were prolonged.
Incorrect. Inflammation does help to prepare the area for repair. Without
inflammation, the platelets would not have aggregated to prevent excessive
blood loss. The area also would not be decontaminated if inflammation did NOT
occur.
Correct. Although inflammation does result in dysfunction, without the
inflammation the area would not be able to repair itself. Inflammation involves a
โself-defenseโ response, which is a prerequisite to healing.
Incorrect. Inflammation does result in vasodilation of the injured vessels to
increase the blood flow, which helps to initiate the release of macromolecules
from the vascular system into the interstitial spaces to restore osmotic pressure to
the area.
PTS: 1
8. ANS: A
KEY: inflammation | wounds | tissue repair
Feedback
A
B
C
D
Correct. Resurfacing of the infrastructure of the wound occurs with epithelial
tissue that is one cell layer thick.
Incorrect. The tissue has small vascular buds that grow into the wound area,
eventually joining to form a capillary loop. This is incapable of producing heat at
this stage of healing unless infection is present.
Incorrect. The tissue is in the process of forming epithelial tissue to rebuild and
restructure and to cover the surfaces of the wound. Resurfacing of the
infrastructure of the wound occurs with epithelial tissue that is one cell layer
thick.
Incorrect. There is a significant amount of irregularity between the edges of the
wound and the interior of a wound during this early stage in the healing process,
with the interior just beginning to resurface.
PTS: 1
9. ANS: D
KEY: tissue repair | proliferation
Feedback
A
B
C
D
Incorrect. Scar tissue is NOT as strong as the tissue it replaces.
Incorrect. Scar tissue is NOT stronger than the tissue it replaces. This is a
common myth that must be overcome with clinicians and patients.
Incorrect. Although this is an accurate statement, it is not the most accurate of
the options. Scar tissue is 70% as strong as the tissue it replaces, which was the
option in D.
Correct. Scar tissue is only 70% as strong as the tissue it replaces, which is one
of the underlying reasons that the surrounding area must be strengthened.
PTS: 1
10. ANS: D
KEY: scar tissue | tissue repair
Feedback
A
B
C
D
Incorrect. Dirt in a wound is one of the indications to leave the wound open to
allow it to granulate and re-epithelialize on its own.
Incorrect. Infection in a wound is one of the indications to leave the wound open
to allow it to granulate and re-epithelialize on its own so that the infection can be
treated and observed.
Incorrect. Excessive drainage from a wound is one of the indications to leave the
wound open to allow it to granulate and re-epithelialize on its own so that the
drainage can be monitored, treated, and observed.
Correct. When the physical condition of the patient is poor or compromised due
to the woundโs location or size, the wound will probably need to be closed by
surgical intervention to help stabilize the patient.
PTS: 1
11. ANS: D
KEY: tissue repair | first intention | second intention
Feedback
A
B
C
D
Incorrect. Potassium, serotonin, and histamine are released in response to injury
as a normal part of the inflammatory process.
Incorrect. Potassium, serotonin, and histamine are released in response to injury
as a normal part of the inflammatory process.
Incorrect. Potassium, serotonin, and histamine are released in response to injury
as a normal part of the inflammatory process.
Correct. Glucose is not released in response to injury as a normal part of the
inflammatory process.
PTS: 1
12. ANS: A
KEY: endogenous substances | inflammation
Feedback
A
B
C
D
Correct. Non-steroidal anti-inflammatory medications often cause GI irritation,
mental confusion, drowsiness, and hypersensitivity.
Incorrect. Codeine is a narcotic drug that can produce physical addiction.
Incorrect. Morphine is a narcotic drug that can produce physical addiction.
Incorrect. Serotonin is not a prescribed medication; it is an endogenous
substance.
PTS: 1
13. ANS: C
KEY: endogenous substances | non-steroidal anti-inflammatory drugs
Feedback
A
B
C
D
Incorrect. A myotome is the muscle that is supplied by a specific nerve root.
Incorrect. A sclerotome is the bone that is supplied by a specific nerve root.
Correct. A dermatome is the sensory area of skin supplied by a specific nerve
root.
Incorrect. Organs are also innervated by specific spinal cord levels.
PTS: 1
14. ANS: C
KEY: dermatomes | referral patterns of pain | myotomes | innervation
Feedback
A
B
C
D
Incorrect. Motor fibers are those portions of the nerve that are responsible for
eliciting a contractile response in the motor units of the muscle.
Incorrect. Mechanoreceptors receive mechanical stimuli such as pressure from
sound or touch.
Correct. A nociceptor is a pain receptor; there are three distinct types.
Incorrect. Thermoreceptors are stimulated in response to a rise in body
temperature.
PTS: 1
15. ANS: A
KEY: sensory receptors | nociceptors | mechanoreceptors | thermoreceptors
Feedback
A
B
C
D
Correct. A-delta fibers conduct impulses at a faster rate than small, unmyelinated
C-fibers.
Incorrect. A-delta fibers conduct impulses at a faster rate than C-fibers, which
are small and unmyelinated.
Incorrect. A-delta fibers conduct impulses at a faster rate than small,
unmyelinated C-fibers.
Incorrect. Mechanoreceptors are NOT nociceptors (pain fibers).
PTS:
1
KEY: nociceptors | conduction velocity | mechanoreceptors
16. ANS: D
Feedback
A
B
C
D
Incorrect. Although the statement is true, the length of time that the symptom
has been experienced is not what makes it difficult to localize.
Incorrect. Chronic pain is difficult to localize.
Incorrect. A-beta fibers carry sensory and mechanoreceptive stimuli, NOT
painful stimuli, which make this statement inaccurate.
Correct. Nociceptors is the category of pain fibers that includes A-delta and
C-fibers. These fibers travel several segments prior to transmitting signals into
the spinal gray matter.
PTS: 1
17. ANS: C
KEY: chronic pain | nociceptors | mechanoreceptors
Feedback
A
B
C
D
Incorrect. Wide-dynamic-range cells are responsible for the localization of
burning or prickling.
Incorrect. Wide-dynamic-range cells are responsible for the localization of
touch.
Correct. Stimuli produced by motion are carried by mechanoreceptive cells.
Incorrect. Wide-dynamic-range cells are responsible for the localization of
noxious stimuli.
PTS: 1
18. ANS: C
KEY: wide-dynamic-range cells | nociceptors
Feedback
A
B
C
D
Incorrect. Although pain is a unique experience for all individuals and can be
qualified only by the individual experiencing it, this is not the most basic aspect
of the gate control theory.
Incorrect. Although psychological factors do influence pain perception, making
it difficult to accurately quantify, the gate control theory does not attempt to deal
with this issue.
Correct. This is the most basic application of the gate control theory. This
mechanism is also thought to be the reason why, instinctively, we provide
sensory stimuli to an injured area to help relieve pain.
Incorrect. Although there is an interaction of peripheral and central mechanisms
that may or may not elicit a painful response to noxious stimuli, this is not the
most basic application of the gate control theory. Sensory stimuli can inhibit
painful stimuli from reaching the brain. This mechanism is also thought to be the
reason why, instinctively, we provide sensory stimuli to an injured area to help
relieve pain.
PTS: 1
19. ANS: A
KEY: pain theories | gate control theory
Feedback
A
B
C
D
Correct. Experimental pain does not have the psychological components to deal
with results that are commonly associated with clinical pain syndromes.
However, data collected may provide insight into potential pain pathways that
have not yet been explored.
Incorrect. The sensations are the same regardless of the method of production.
However, the psychological component is absent, which makes extrapolation of
data from experimental studies not directly applicable to clinical pain
syndromes.
Incorrect. Experimental pain is not easier to produce than clinical pain.
However, it is useful for research purposes. Data collected may provide insight
into potential pain pathways that have not yet been explored.
Incorrect. Clinical pain is unique to each individual. However, experimental pain
is useful for research purposes. Data collected may provide insight into potential
pain pathways that have not yet been explored.
PTS: 1
20. ANS: D
KEY: pain perception | clinical pain | experimental pain
Feedback
A
B
C
D
Incorrect. Transudates appear first and easily dissipate due to the lack of cells
within them, which makes them clear and watery.
Incorrect. Plasma proteins that enter the interstitial space cause the edema to
become cloudy and thick. Although they assist in the decontamination of the
area, they are not the first event that assists the lymphatic system to flush the
area and decontaminate it from necrotic tissues.
Incorrect. Exudates do not represent the presence of infection. There can be
exudates in both infected and uninfected tissues. An odor is more indicative of
an infection than exudates. It is not uncommon for exudates to help maintain the
moisture of the wound bed to assist in the healing process.
Correct. Pus contains large numbers of white blood cells and is often difficult to
reduce.
PTS:
1
KEY: tissue repair | edema | exudates | transudates | pus
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